The influence of small amount of substances present in tissue on immunosuppressive drug optical spectrum

Authors

  • Marcin Jarosław Marzejon Gdańsk University of Technology Faculty of Electronics, Telecommunications and Informatics Department of Metrology and Optoelectronics Institute of Physical Chemistry Polish Academy of Sciences http://orcid.org/0000-0001-8674-0437
  • Małgorzata Jędrzejewska-Szczerska Gdańsk University of Technology Faculty of Electronics, Telecommunications and Informatics Department of Metrology and Optoelectronics

DOI:

https://doi.org/10.4302/plp.v10i3.831

Abstract

In this paper, we describe how commonly present in tissue substances - sodium chloride and glucose - affect the optical spectrum of an immunosuppressive drug (Cyclaid® by Apotex). Prepared samples were investigated using the spectrophotometer in the spectrum range from 250 nm to 1100 nm. The maximum wavelength shift calculated on the basis of measurement results is not bigger than the measurement wavelength step. So, it can be concluded, that the small amount of sodium chloride or glucose does not influence the measurement and it is possible to apply spectrophotometry in a point-of-care sensor of the Cyclaid® by Apotex level.

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References
  1. L. Taylor, C. J. E. Watson, and J. A. Bradley, "Immunosuppressive agents in solid organ transplantation: Mechanisms of action and therapeutic efficacy", Crit. Rev. Oncol. Hematol. 56, 23 (2005). CrossRef
  2. C. C. Mok, "Calcineurin inhibitors in systemic lupus erythematosus", Best Pract. Res. Clin. Rheumatol. 31, 429 (2017). CrossRef
  3. C. E. M. Griffiths et al., "Striae gravidarum in primiparae", Br. J. Dermatol. 155, 1 (2006). CrossRef
  4. F. Stucker and D. Ackermann, "Immunsuppressiva - Wirkungen, Nebenwirkungen und Interaktionen", Ther. Umschau. Rev. thérapeutique, 68 ,679 (2011). CrossRef
  5. A. Fahr, "Cyclosporin Clinical Pharmacokinetics", Clin. Pharmacokinet. 24, 472 (1993). CrossRef
  6. Cyclosporine – UpToDate, DirectLink
  7. P. Strakowska, R. Beutner, M. Gnyba et al., "Electrochemically assisted deposition of hydroxyapatite on Ti6A14V substrates covered by CVD diamond films – coating characterization and first cell biological results", Mater Sci Eng C Mater Biol Appl. 59, 624 (2016). CrossRef
  8. M. Gnyba, M. S. Wróbel, K. Karpienko et al., "Combined analysis of whole human blood parameters by Raman spectroscopy and spectral-domain low-coherence interferometry", Proc. SPIE 9537, 95371N (2015). CrossRef
  9. M. S. Wróbel, M. Gnyba, R. Urniaz et al., "Detection of propofol concentrations in blood by Raman spectroscopy", Proc. SPIE 9537, 95370Z (2015). CrossRef
  10. M. Gnyba, et al., "SAVE TO MY LIBRARY Raman spectroscopic investigation of blood and related materials", Proc. SPIE 9448, 944809 (2015). CrossRef
  11. H. S. Cho et al., "High frame-rate intravascular optical frequency-domain imaging in vivo", Biomed. Opt. Express 5, 223 (2013). CrossRef
  12. T. A. Valdez et al., "Multi-color reflectance imaging of middle ear pathology in vivo", Anal. Bioanal. Chem. 407, 3277 (2015). CrossRef
  13. M. Ali Ansari, S. Alikhani, and E. Mohajerani, "A hybrid imaging method based on diffuse optical tomography and optomechanical method to detect a tumor in the biological phantom", Opt. Commun. 342, 12 (2015). CrossRef
  14. M. S. Wróbel et al., "Multi-layered tissue head phantoms for noninvasive optical diagnostics", J. Innov. Opt. Health Sci. 08, 1541005 (2015). CrossRef
  15. D. A. Skoog, F. J. Holler, and S. R. Crouch, Principles of instrumental analysis, (Belmont, CA, Thomson Brooks/Cole 2007). CrossRef
  16. M. Hof, Basics of Optical Spectroscopy in Handbook of Spectroscopy, (Weinheim , Wiley-VCH Verlag GmbH & Co. KGaA 2005). CrossRef
  17. M. Marzejon et al,. "Optical-Spectrometry-Based Method for Immunosuppressant Medicine Level Detection in Aqueous Solutions", Sensors, 18, 2001 (2018). CrossRef
  18. UV-9000 Double Beam UV/VIS, http://en.metash.com/ProductShow_172.html CrossRef

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Published

2018-10-01

How to Cite

[1]
M. J. Marzejon and M. Jędrzejewska-Szczerska, “The influence of small amount of substances present in tissue on immunosuppressive drug optical spectrum”, Photonics Lett. Pol., vol. 10, no. 3, pp. 79–81, Oct. 2018.

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